BRMEC8 Colloquium Approaches - #BRMEC8

Eight Years of Forging International Collaboration in Research into ME

The 8th Biomedical Research into ME Colloquium is approaching and we are looking forward to yet another IiMER international event which again has all of the leading centres of research, and researchers from around the world working together for the benefit of people with ME.

The Colloquium is just one of eight events organised by Invest in ME Research during ME Conference Week 2018.

The Colloquiums allow a lot of time for informal discussions and we have found these to be extremely useful in progressing research activities into ME.

Drs Whittemore, Nath and Unger from NIH and CDC will give updates on USA government-funded activities and they will get to hear from the top European and Australian researchers.

Mady Hornig from Center for Infection and Immunity (CII) at the Columbia University Mailman School of Public Health has been a regular to IiMER colloquiums and conferences and she will talk about increasing diagnostic accuracy using empirical and data driven approaches.

The Microbiome session will include a presentation by the IiMER funded Quadram Institute Bioscience PhD students and a talk on a new clinical trial, the Comeback study, by Peter Johnsen in Tromsø, Norway.

The Tromsø team are collaborating with Cornell University and Quadram Institute Bioscience so we are pleased to welcome another of our regular attendee Maureen Hanson to chair the session as well as presenting on cell metabolism later on in the day.

We also welcome back our friends from Haukeland University hospital in Bergen - the Norwegian RituxME research team - who brought ME to the map of mainstream research and media attention.

They will discuss their clinical trials using rituximab and cyclophosphamide to treat ME patients. They have built up an impressive ME research biobank and it is being put into good use by looking at metabolomics and their colleague Karl Johan Tronstad has been studying cellular energetics in particular.

IiMER are also welcoming additional researchers from Haukeland University hospital in order to increase collaboration and knowledge.

Angela Vincent from Oxford University will present results of her lab’s efforts in finding neuronal antibodies in the samples sourced from the Norwegian rituximab trial participants.

The Oxford lab is a world-renowned specialist in this area and best placed for this type of research.

As always we also include researchers from outside the usual ME field and Naomi Allen, Senior Epidemiologist for UK Biobank and an Associate Professor of Epidemiology at the University of Oxford, will talk about this global resource and its possibilities for ME research. The resource has recently been in the news in connection with a number of discoveries
such as new genes being discovered for osteoarthritis and genetic basis discovery for skin cancer. {]

An article from the UK Biobank will appear in our Conference Journal of IiMER.

Another new contributor from outside the ME field is Samuel Fountain whose expertise is in purinergic signalling.
We covered some of this interesting and important area some years ago with the help of Professor Geoffrey Burnstock, the “father” of purinergic signalling, and we are pleased that we have expert help in this area once again to give ideas and help to the established ME researchers.

Metabolomics is an area that is being studied by many research groups and it will be interesting to hear whether results from different groups support each other and gain agreement on the importance of common methodologies.

Professor Karl Johan Tronstad could not make it last year to the Colloquium so we are happy that he is able to present at the Conference, and will also be presenting at the Colloquium in this topic segment.

Ron Davis returns with an update from Stanford Genome and

Karl Morten was invited and attended our Colloquium several years ago. Karl is back again speaking in this segment.

This topic segment will be chaired by Professor Jonas Bergquist from Uppsala University in Sweden.

Another of the new presenters at the Colloquium will be Heikki Hyöty who will present on the role of enteroviruses in type one diabetes which will have relevance and maybe lessons to be learned regarding Dr Chia’s research into enteroviruses and ME.

HPV and autoimmunity will be covered by a new attendee from Denmark, Jesper Mehlsen.

The session will be chaired by virology expert, Tom Wileman.

Mast cells are increasingly being connected to ME and the topic is being covered by mast cell expert Theoharis Theoharides.
He will be giving the first Anne Ortegren memorial Lecture held in honour of our Swedish friend who passed away earlier this year.

We are very pleased to welcome Ben Seddon in the immunology topic segment to discuss T cells and their role in ME.

Another new presenter Malav Trivedi from Miami will talk about his hypothesis of oxidative stress and reprogramming peripheral blood mononuclear cells (PBMCs) to Induced Pluripotent Stem Cells (iPSCs) and then to neurons.

Lesley Hoyles will be presenting on understanding the gut microbiome using a systems biology approach and Travis Craddock is returning to the IiMER colloquium to present on using machine learning to differentiate subgroups of ME patients.

Kristian Sommerfelt will provide some real life experience of paediatric patients and their symptoms.

Markku Partinen, as a renowned sleep specialist, will provide insight into data relating to sleep and ME.

Biomarkers are being explored by many research groups and we will have presentations on autoantibodies, proteomics, steroids, CSF miRNA, genetic and immunogenetic studies in ME.

The BRMEC8 home page with agenda is here -

Countries belonging to the European ME Alliance (EMEA) and others will be represented and present at the preconference and post-conference dinners to allow patient perspectives to discussed and heard and EMEA look to add new members to the Alliance this year.

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Last Update 06/05/2018


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